Question: How long does it take to see results correcting iron overload once I start giving the Uckele Copper and Zinc supplements? I'm dealing with laminitis and IR issues. Thank you. Dr. Kellon: It takes several months to a year before laboratory values begin to drop but you may see improved hoof quality before that. The most important thing with laminitis and IR is to control the simple carbohydrate intake because that is what drives the insulin.